4) Fantastic Four
Stan Lee’s influence on superhero comics cannot be overstated – and it all started with the Fantastic Four of Mr. Fantastic, the Invisible Woman, the Human Torch and the Thing.
What Lee did that hadn’t been done before was to root the superheroics in the characters; in their interpersonal conflicts and friendships as a family unit. There’s Reed and Ben’s bromance, Sue and Reed’s marriage, Johnny and Sue’s brother/sister bond, etc. Unlike other teams that can fall apart at the smallest provocation, the Fantastic Four can’t be broken (at least not for good).
In recent years, the Fantastic Four have sadly been written out of continuity due to 20th Century Fox holding the movie rights to the characters. At least they went out with a bang though: Reed Richards saved the multiverse from Doctor Doom, sending him and his family off into another dimension. Rest assured, though, that Marvel’s First Family are not gone for ever.